pre by the iO clinic estra balance 1.75 oz (50 g) treatment for estrogen-deficient menopausal skin
PRE by the iO Clinic Estra Balance 1.75 oz frosted glass pump bottle for estrogen-deficient menopausal skin.
pre EstraBalance by The iO Clinic x SGMD - set of three
PRE Estra Balance 50 g product image
pre by the iO clinic estra balance 1.75 oz (50 g) treatment for estrogen-deficient menopausal skin
PRE by the iO Clinic Estra Balance 1.75 oz frosted glass pump bottle for estrogen-deficient menopausal skin.
pre EstraBalance by The iO Clinic x SGMD - set of three
PRE Estra Balance 50 g product image

Pre - Estra Balance 50 g

Developed by our own physicians: plant-based phytoestrogens that restore vitality to estrogen-deficient skin.
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Regular price
$220.00 USD
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$220.00 USD
Regular price
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Judgment: chosen by surgeons who see thousands of outcomes, not by a buyer or an algorithm.
Authenticity: authorized channel, direct from the brands, no gray-market risk.
Continuity: the care doesn't stop when the patient leaves the practice.

pre estra balance is a nourishing balm developed by gynecologist Dr. Sally Greenwald together with facial plastic surgeons Dr. David Lieberman and Dr. Sachin Parikh, formulated to address the visible signs of estrogen-deficient skin.

As estrogen declines, skin loses collagen, elasticity, and its ability to hold water, often faster than at any other point in life. The formula uses plant-derived phytoestrogens that act locally in the skin without meaningfully stimulating other estrogen-sensitive tissues, which is what makes it appropriate for all women to use.

Soybean seed extract provides naturally occurring isoflavones, studied for their role in supporting skin firmness and collagen integrity as estrogen levels decline. A growth factor and a synergistic blend of peptides help promote skin renewal and resilience, while niacinamide, stabilized vitamin C, vitamin E, and ferulic acid deliver antioxidant protection and refine tone. Rich emollients, ceramides, and squalane restore barrier function for improved comfort and radiance.

It is paraben-free, fragrance-free, and dye-free. Size: 1.75 oz / 50 g.

1. Use estra balance in the morning as your first product, applied to clean skin.
2. Because it contains advanced forms of vitamin C and ferulic acid, it can replace your morning antioxidant serum.
3. Follow with a mineral-based SPF.
4. For a complementary nighttime product, consider Plated Intense Serum.

Always consult your medical provider before incorporating a new skincare product, particularly if you have a history of hormone-sensitive cancer.

Plant-Based Phytoestrogens: provide the skin benefits of estrogen signaling locally, without systemic activation.

Soybean Seed Extract: supplies naturally occurring isoflavones, studied for their role in supporting skin firmness and collagen integrity as estrogen declines.

Growth Factor and Peptide Blend: support skin regeneration, repair, and collagen production.

Niacinamide, Stabilized Vitamin C, Vitamin E, and Ferulic Acid: deliver antioxidant protection and refine the appearance of tone.

Ceramides, Squalane, and Rich Emollients: restore barrier function for improved comfort and radiance.

Paraben-free, an important consideration for women seeking to minimize exposure to potential endocrine disruptors. Fragrance-free and dye-free.

• Backed by three board-certified physicians: Dr. Sally Greenwald, Dr. David Lieberman, and Dr. Sachin Parikh.
• Rich in plant-based phytoestrogens that provide the skin benefits of estrogen signaling without systemic activation.
• Growth factors support skin regeneration, repair, and collagen production.
• Antioxidant complex means it can replace a morning antioxidant serum.
• Restores barrier function for improved comfort and radiance.
• Paraben-free, fragrance-free, and dye-free.
• Suitable for normal, dry, or combination skin, estrogen-deficient skin, photoaged and sagging skin, uneven tone, and skin unable to tolerate retinoids.

This product exists because our own physicians saw a gap. Patients in perimenopause and menopause described skin that had stopped behaving the way it always had, and the available answers were either generic moisturizers or systemic hormone therapy with its own considerations.

The design intent is local action. Phytoestrogens act in the skin without meaningfully stimulating other estrogen-sensitive tissues, which is what allows a wider range of women to use it. It is also a useful option for patients who cannot tolerate retinoids, since it addresses firmness and tone through an entirely different mechanism.

One clear caution: if you have a history of hormone-sensitive cancer, discuss this with your oncologist before use, however local the action is. Skincare supports skin quality through hormonal change; it does not substitute for a medical conversation about hormonal health. You can order this here without an appointment, and we ship nationwide.

Pre - Estra Balance 50 g
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